Figure 7From: Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytesModels of eotaxin-1 function on MMP-1 gene expression and protein secretion in human chondrocytes. (A) Eotaxin-1 binds G protein-coupled CCRs, such as CCR3, and induces MMP-3 expression through cAMP/PKA inhibition and MAP kinase activation. (B) Eotaxin-1 at low concentrations is able to promote MMP-3 release from the cells by activating PLC/PKC and MAP kinase pathways.Back to article page