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Figure 4 | Journal of Biomedical Science

Figure 4

From: Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias

Figure 4

Nse-BMP4;Nse-Noggin double transgenic mice show only subtle hyperplasia of hair follicles. Representative H&E staining from WT (A), Nse-Noggin (B), Nse-BMP4 (C) and Nse-Noggin; Nse-BMP4 double transgenic mice (D) show histological features in different lines of animals. Note that crossing the Nse-Noggin mice with Nse-BMP4 mice rescued the tumor phenotype seen in Nse-Noggin mice (comparing B&D), but subtle hyperplasia of hair follicles is still observable in (D). Bar = 40 μm (E) summary of severity of tumorigenesis in different lines.

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Journal of Biomedical Science

ISSN: 1423-0127