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Figure 7 | Journal of Biomedical Science

Figure 7

From: Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

Figure 7

Structure-activity relationship of briarane-type diterpenes that confer the inhibition of LPS-induced IL-6 expression in mouse BMDCs. (A) Chemical structures of briarane-type diterpenes 1 to 8. The numbers labeling BrD1 indicate the carbon atoms. (B) The chemical structure of BrD1, and its analogs including BrD1-5C, BrD1-6C, BrD1-7C and BrD1-10C. (C) The chemical structure of BrD1, and its analogs including BrD1-5C, BrD1-6C, BrD1-7C and BrD1-10C. Immature DCs were co-treated with LPS and BrDs at 20 μM. The level of IL-6 proteins in supernatants was determined using ELISA. ***, P < 0.001 versus LPS+BrD1 treatment. Data are representative of two independent experiments.

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Journal of Biomedical Science

ISSN: 1423-0127