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Table 1 Inhibitory effect of briarane-type diterpenes from marine coral Briareum excavatumon on LPS-induced IL-6 in mouse BMDCs.

From: Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

IL-6 (% of LPS control)

Code

Name (20 μM)

% (Mean ± SD)

BrD1

Excavatolide

B

2.4 ± 0.93

BrD2

Excavatolide

K

22.5 ± 4.5

BrD3

Excavatolide

F

26.2 ± 4.0

BrD4

Briaexcavatolide

R

34.7 ± 8.6

BrD5

Excavatolide

Z

37.0 ± 9.6

BrD6

Briaexcavatolide

B

56.6 ± 2.1

BrD7

Briaexcavatolide

K

61.3 ± 9.5

BrD8

Briaexcavatolide

H

81.3 ± 1.9

  1. IL-6 in supernatants of diterpenes BrD1 to BrD8 were determined by using a standard sandwich ELISA. Results are expressed as a percentage of LPS-induced IL-6 expression.
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Journal of Biomedical Science

ISSN: 1423-0127