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Table 3 Logistic regression analysis of the relationship between Gly1057Asp polymorphism in IRS-2 and CAD*

From: Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population

  Odds ratio (95% CI) (Univariate analysis) P value Odds ratio (95% CI) (Multivariate analysis) P value
Genotype     
 Asp/Asp(n = 87) reference   reference  
 Gly/Gly + Gly/Asp(n = 367) 1.957 (1.220-3.139) 0.005 2.008 (1.210-3.332) 0.007
Male 2.240 (1.516-3.309) <0.001 1.969 (1.154-3.358) 0.013
Age, year 1.033 (1.016-1.050) <0.001 1.037 (1.017-1.057) <0.001
Hypertension 1.609 (1.089-2.376) 0.017 1.153 (0.738-1.803) 0.531
Diabetes mellitus 2.054 (1.305-3.232) 0.002 1.847 (1.133-3.009) 0.014
Smoking history 1.981 (1.302-3.012) 0.001 1.521 (0.912-2.536) 0.108
Hypercholesterolemia history 1.559 (1.063-2.286) 0.023 1.308 (0.841-2.032) 0.233
Body mass index(kg/m2) 1.012 (0.960-1.066) 0.667 1.992 (0.936-1.052) 0.796
Total cholesterol(mmol/L) 1.263 (1.037-1.538) 0.020 1.295 (1.028-1.631) 0.028
Serum creatitnine(μmol/L) 1.016 (1.007-1.024) <0.001 1.004 (0.995-1.014) 0.392
  1. IRS: insulin receptor substrate; CAD: coronary artery disease; CI: confidence interval.
  2. * Totally, 284 CAD patients and 170 control subjects were included in analysis.