Table 3 Logistic regression analysis of the relationship between Gly1057Asp polymorphism in IRS-2 and CAD*
| Â | Odds ratio (95% CI) (Univariate analysis) | P value | Odds ratio (95% CI) (Multivariate analysis) | P value |
|---|---|---|---|---|
Genotype | Â | Â | Â | Â |
 Asp/Asp(n = 87) | reference |  | reference |  |
 Gly/Gly + Gly/Asp(n = 367) | 1.957 (1.220-3.139) | 0.005 | 2.008 (1.210-3.332) | 0.007 |
Male | 2.240 (1.516-3.309) | <0.001 | 1.969 (1.154-3.358) | 0.013 |
Age, year | 1.033 (1.016-1.050) | <0.001 | 1.037 (1.017-1.057) | <0.001 |
Hypertension | 1.609 (1.089-2.376) | 0.017 | 1.153 (0.738-1.803) | 0.531 |
Diabetes mellitus | 2.054 (1.305-3.232) | 0.002 | 1.847 (1.133-3.009) | 0.014 |
Smoking history | 1.981 (1.302-3.012) | 0.001 | 1.521 (0.912-2.536) | 0.108 |
Hypercholesterolemia history | 1.559 (1.063-2.286) | 0.023 | 1.308 (0.841-2.032) | 0.233 |
Body mass index(kg/m2) | 1.012 (0.960-1.066) | 0.667 | 1.992 (0.936-1.052) | 0.796 |
Total cholesterol(mmol/L) | 1.263 (1.037-1.538) | 0.020 | 1.295 (1.028-1.631) | 0.028 |
Serum creatitnine(μmol/L) | 1.016 (1.007-1.024) | <0.001 | 1.004 (0.995-1.014) | 0.392 |