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Table 4 Logistic regression analysis of the relationship between genotype-DM interaction and CAD*

From: Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population

  Odds ratio (95% CI) (Univariate analysis) P value Odds ratio (95% CI) (Multivariate analysis) P value
Genotype-DM interaction     
 Nondiabetics:Asp/Asp(n = 68) reference   reference  
 Diabetics:Asp/Asp(n = 18) 1.768 (0.612-5.105) 0.292 1.561 (0.517-4.713) 0.430
 Nondiabetics:Gly/Asp + Gly/Gly(n = 261) 1.782 (1.041-3.050) 0.035 1.922 (1.086-3.400) 0.025
 Diabetics:Gly/Asp + Gly/Gly(n = 107) 3.505 (1.830-6.711) <0.001 3.629 (1.820-7.236) <0.001
Male 2.240 (1.516-3.309) <0.001 1.981 (1.161-3.378) 0.012
Age, year 1.033 (1.016-1.050) <0.001 1.037 (1.017-1.057) <0.001
Hypertension 1.609 (1.089-2.376) 0.017 1.146 (0.742-1.814) 0.514
DM 2.054 (1.305-3.232) 0.002 -# -#
Body mass index(kg/m2) 1.012 (0.960-1.066) 0.667 0.993 (0.937-1.052) 0.802
Hypercholesterolemia history 1.559 (1.063-2.286) 0.023 1.302 (0.837-2.026) 0.241
Smoking history 1.981 (1.302-3.012) 0.001 1.516 (0.908-2.530) 0.112
Total cholesterol(mmol/L) 1.263 (1.037-1.538) 0.020 1.301 (1.033-1.640) 0.026
Serum creatitnine(μmol/L) 1.016 (1.007-1.024) <0.001 1.004 (0.995-1.014) 0.380
  1. DM: diabetes mellitus; CAD: coronary artery disease; CI: confidence interval.
  2. * Totally, 284 CAD patients and 170 control subjects were included in analysis.
  3. # DM was dropped from analysis because the variance inflation factors for DM and genotype-DM interaction were both greater than 10. The variance inflation factor for genotype-DM interaction was less than 2.0 if DM was removed from analysis.