Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population

Table 4 Logistic regression analysis of the relationship between genotype-DM interaction and CAD*

	Odds ratio (95% CI) (Univariate analysis)	P value	Odds ratio (95% CI) (Multivariate analysis)	P value
Genotype-DM interaction
Nondiabetics:Asp/Asp(n = 68)	reference		reference
Diabetics:Asp/Asp(n = 18)	1.768 (0.612-5.105)	0.292	1.561 (0.517-4.713)	0.430
Nondiabetics:Gly/Asp + Gly/Gly(n = 261)	1.782 (1.041-3.050)	0.035	1.922 (1.086-3.400)	0.025
Diabetics:Gly/Asp + Gly/Gly(n = 107)	3.505 (1.830-6.711)	<0.001	3.629 (1.820-7.236)	<0.001
Male	2.240 (1.516-3.309)	<0.001	1.981 (1.161-3.378)	0.012
Age, year	1.033 (1.016-1.050)	<0.001	1.037 (1.017-1.057)	<0.001
Hypertension	1.609 (1.089-2.376)	0.017	1.146 (0.742-1.814)	0.514
DM	2.054 (1.305-3.232)	0.002	-^#	-^#
Body mass index(kg/m²)	1.012 (0.960-1.066)	0.667	0.993 (0.937-1.052)	0.802
Hypercholesterolemia history	1.559 (1.063-2.286)	0.023	1.302 (0.837-2.026)	0.241
Smoking history	1.981 (1.302-3.012)	0.001	1.516 (0.908-2.530)	0.112
Total cholesterol(mmol/L)	1.263 (1.037-1.538)	0.020	1.301 (1.033-1.640)	0.026
Serum creatitnine(μmol/L)	1.016 (1.007-1.024)	<0.001	1.004 (0.995-1.014)	0.380

DM: diabetes mellitus; CAD: coronary artery disease; CI: confidence interval.
* Totally, 284 CAD patients and 170 control subjects were included in analysis.
^# DM was dropped from analysis because the variance inflation factors for DM and genotype-DM interaction were both greater than 10. The variance inflation factor for genotype-DM interaction was less than 2.0 if DM was removed from analysis.

ISSN: 1423-0127