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Figure 1 | Journal of Biomedical Science

Figure 1

From: The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

Figure 1

Effects of MF on baseline heart rate, sympathetic nerve activity and phrenic nerve activity. (A) Example, original traces showing baseline heart rate, sympathetic nerve and phrenic nerve activity during control, MF and washout. Heart rate significantly decreases (B) and PND rate significantly increases due to a significant reduction in the Te duration (seconds) (C and D) upon the application of MF to the perfusate, the effects are reversed after washout. Asterisks denote significance.

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Journal of Biomedical Science

ISSN: 1423-0127