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Figure 2 | Journal of Biomedical Science

Figure 2

From: The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

Figure 2

MF induces bradycardia during parasympathetic blockade with atropine. (A) Example, original traces showing baseline heart rate, sympathetic and phrenic nerve activity and perfusion pressure during control. (B) Addition of 1 μM atropine to the perfusate resulted in significantly increased heart rate and abolished respiratory sinus arrhythmia, indicative of parasympathetic blockade. (C) MF induces a bradycardia in the presence of atropine. (D) Average heart rate (n=4) is significantly increased from control in the presence of atropine. In the presence of atropine MF significantly decreased HR.

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Journal of Biomedical Science

ISSN: 1423-0127