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Figure 4 | Journal of Biomedical Science

Figure 4

From: The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

Figure 4

MF augments PND discharge rate increase following chemoreceptor stimulation. (A-C) Upon chemoreceptor stimulation (arrow) during control, MF and wash, a pronounced sympathoexcitation in ∫SND occurs and respiratory rate increases. Analysis of respiratory variables reveals no significantly different increase in Ti, Te or Ttot duration from baseline however, the PND rate significantly increased with MF compared to control and wash (D). Asterisks denote significance, NS; not significant.

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Journal of Biomedical Science

ISSN: 1423-0127