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Figure 1 | Journal of Biomedical Science

Figure 1

From: Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats

Figure 1

Intravenous injection of ketamine dose-dependently inhibited pressor effects induced by intrathecal NMDA. (a) Representative recordings of changes in blood pressure induced by an intrathecal injection of NMDA (2 nmol, indicated by an arrow) and the changes in NMDA-induced pressor responses at 10 and 40 min after a single intravenous injection of ketamine (2 or 4 mg/kg). NMDA was applied intrathecally every 30 min. (b and c) Bar graphs show the time course of the percentage changes in NMDA-induced increases in mean arterial pressure (MAP, b) and blood ketamine concentration (c) following intravenous injection of two doses of ketamine (2 and 4 mg/kg). The peak magnitude of NMDA-induced increase in MAP immediately prior to application of ketamine is taken as control (100%).*Significant difference from control analyzed using the repeated measure ANOVA followed by Newman-Keuls post-test.

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