Table 2 Description of top 20 differentially expressed Wolbachia genes found in doxycycline treated Brugia malayi female worms
From: Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
Functional class | Systematic | Annotation# | Fold change | P-value | Signal | Description |
|---|---|---|---|---|---|---|
Protein synthesis | ||||||
| Â | BMX14197 | w Bm0431 | 0.12 | 1.84E-05 | Down | DNA-directed RNA polymerase sigma 32 subunit, RpoH |
| Â | BMX14096 | w Bm0328 | 0.11 | 4.19E-05 | Down | Ribosomal protein S14 |
| Â | BMX14288 | w Bm0521 | 0.23 | 7.90E-05 | Down | Ribosomal protein S21 |
| Â | BMX14418 | w Bm0650 | 0.12 | 9.18E-05 | Down | Ribosomal protein L1 |
| Â | BMX14100 | w Bm0332 | 0.10 | 9.84E-05 | Down | Ribosomal protein S17 |
| Â | BMX14101 | w Bm0334 | 0.19 | 1.01E-04 | Down | Ribosomal protein L16 |
| Â | BMX14113 | w Bm0346 | 0.16 | 1.14E-04 | Down | Ribosomal protein S12 |
| Â | BMX14026 | w Bm0258 | 0.21 | 5.92E-05 | Down | Ribonuclease D |
DNA replication, DNA recombination, DNA repair or SOS response | ||||||
| Â | BMX14200 | w Bm0434 | 0.06 | 1.56E-05 | Down | DNA polymerase III, gamma/tau subunit |
| Â | BMX14193 | w Bm0427 | 0.25 | 5.30E-05 | Down | RecA recombinase |
| Â | BMX14131 | wBm0365 | 3.06 | 1.19E-03 | Up | Predicted EndoIII-related endonuclease |
| Â | BMX14476 | w Bm0708 | 0.13 | 1.22E-04 | Down | Superfamily II DNA/RNA helicase |
Energy production and conversion | ||||||
| Â | BMX14457 | w Bm0689 | 0.09 | 8.65E-05 | Down | F0F1-type ATP synthase, beta subunit |
| Â | BMX14240 | wBm0474 | 3.16 | 1.49E-03 | Up | NADH:ubiquinone oxidoreductase |
Metabolism & Transport | Â | Â | Â | Â | Â | |
| Â | BMX14214 | w Bm0448 | 0.14 | 1.40E-04 | Down | Succinate dehydrogenase flavoprotein subunit, SdhA |
| Â | BMX13916 | w Bm0146 | 0.23 | 1.38E-04 | Down | Kef-type K+ transport system, membrane component |
| Â | BMX13899 | w Bm0129 | 0.27 | 1.09E-04 | Down | Ornithine/acetylornithine aminotransferase |
| Â | BMX13796 | w Bm0024 | 0.15 | 1.06E-05 | Down | HesB/YadR/YfhF family protein |
Secretion | ||||||
| Â | BMX14563 | w Bm0795 | 0.18 | 1.27E-04 | Down | Type IV secretory pathway, VirB6 components |
Immunogenic membrane components | Â | Â | Â | Â | ||
| Â | BMX14198 | w Bm0432 | 0.06 | 1.21E-04 | Down | Outer surface protein-wsp |