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Table 3 Major known differentially expressed* Brugia malayi genes after doxycycline treatment

From: Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo

Functional class

Sequence

OligoID

Fold change

P value

Description

Pub_Locus

Up-regulated

Electron transfer

     
 

BMC05513

bm.01224

5.12

1.04E-03

Cytochrome C oxidase

Bm1_53760

 

14963.m01788

BMX5456

2.66

3.13E-03

Ubiquinol-cytochrome-c oxidase activity

Bm1_34585

 

BMC01497

bm.00393

3.55

6.56E-03

ATP synthase F0 subunit 6

 

Antioxidants

 

14981.m02381

BMX7492

2.85

1.72E-03

Thioredoxin

Bm1_46710

Proteases

 

BMW00062.466

BMX11239

3.12

1.42E-03

Cathepsin L-like cysteine proteinase

Bm1_00065

 

13332.m00193

BMX1173

2.65

4.18E-03

Metalloprotease

Bm1_07750

 

13632.m00184

BMX1614

2.01

7.91E-03

Trypsin family protein

Bm1_10665

Metabolism and transport

 

14773.m00936

BMX4045

2.67

5.91E-03

Pyruvate dehydrogenase

Bm1_25865

 

13478.m00071

BMX1447

2.00

5.55E-03

Malate/L-lactate dehydrogenase

Bm1_09530

 

14981.m02410

BMX7517

3.61

3.27E-04

Biopterin-dependent aromatic amino acid

hydroxylase

Bm1_46865

 

14787.m00179

BMX4095

13.7

7.23E-06

Cysteine-rich, acidic integral membrane protein precursor, putative

Bm1_15145

Immunogens

 

14222.m00064

BMX2433

10.3

2.76E-05

PPE family protein, putative

Bm1_15875

 

BMC05381

bm.01203

2.13

4.10E-03

BmSERPIN

Bm1_03995

 

12920.m00009

BMX601

2.49

6.84E-03

Excretory/secretory protein Juv-p120

Bm1_04050

 

BMC00351

bm.03044

2.27

2.65E-03

Vespid venom allergen

antigen-like protein 1

Bm1_14040

 

14399.m00013

BMX2941

2.51

7.90E-04

ALT protein

Bm1_14360

 

13893.m00088

BMX1920

4.25

3.08E-03

IgG and IgE immunoreactive antigen

Bm1_12575

 

BMC00480

bm.00167

4.40

2.76E-03

mmc1

#N/A

 

13673.m00036

BMX1683

3.03

1.05E-03

Mucin

Bm1_11110

Down-regulated

Reproduction, development & transport

 

BMC00903

bm.00277

0.47

2.78E-03

Embryonic fatty acid-binding protein

Bm-FAB-1

Bm1_33050

 

12495.m00012

BMX108

0.26

8.99E-03

Collagen, putative

Bm1_00775

 

15377.m00007

BMX9051

0.21

1.75E-03

Alpha-1 collagen type IX, putative

Bm1_56350

 

AA109462

BMX9336

0.40

5.12E-03

Peptidyl-prolyl cis-trans isomerase

Bm1_56870

 

BMC03244

bm.00803

0.45

4.98E-03

Prolyl 4-hydroxylase

Bm1_45455

 

BMC02383

bm.00595

0.44

6.93E-04

Caveolin-1

Bm1_36280

 

14700.m00144

BMX3736

0.42

4.38E-03

Cadherin

Bm1_24010

Electron transfer

 

BMC02188

bm.00554

0.30

2.20E-03

NADH dehydrogenase subunit 5

Bm1_56750