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Table 3 Major known differentially expressed* Brugia malayi genes after doxycycline treatment

From: Effects of Doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo

Functional class Sequence OligoID Fold change P value Description Pub_Locus
Up-regulated
Electron transfer      
  BMC05513 bm.01224 5.12 1.04E-03 Cytochrome C oxidase Bm1_53760
  14963.m01788 BMX5456 2.66 3.13E-03 Ubiquinol-cytochrome-c oxidase activity Bm1_34585
  BMC01497 bm.00393 3.55 6.56E-03 ATP synthase F0 subunit 6  
Antioxidants
  14981.m02381 BMX7492 2.85 1.72E-03 Thioredoxin Bm1_46710
Proteases
  BMW00062.466 BMX11239 3.12 1.42E-03 Cathepsin L-like cysteine proteinase Bm1_00065
  13332.m00193 BMX1173 2.65 4.18E-03 Metalloprotease Bm1_07750
  13632.m00184 BMX1614 2.01 7.91E-03 Trypsin family protein Bm1_10665
Metabolism and transport
  14773.m00936 BMX4045 2.67 5.91E-03 Pyruvate dehydrogenase Bm1_25865
  13478.m00071 BMX1447 2.00 5.55E-03 Malate/L-lactate dehydrogenase Bm1_09530
  14981.m02410 BMX7517 3.61 3.27E-04 Biopterin-dependent aromatic amino acid
hydroxylase
Bm1_46865
  14787.m00179 BMX4095 13.7 7.23E-06 Cysteine-rich, acidic integral membrane protein precursor, putative Bm1_15145
Immunogens
  14222.m00064 BMX2433 10.3 2.76E-05 PPE family protein, putative Bm1_15875
  BMC05381 bm.01203 2.13 4.10E-03 BmSERPIN Bm1_03995
  12920.m00009 BMX601 2.49 6.84E-03 Excretory/secretory protein Juv-p120 Bm1_04050
  BMC00351 bm.03044 2.27 2.65E-03 Vespid venom allergen
antigen-like protein 1
Bm1_14040
  14399.m00013 BMX2941 2.51 7.90E-04 ALT protein Bm1_14360
  13893.m00088 BMX1920 4.25 3.08E-03 IgG and IgE immunoreactive antigen Bm1_12575
  BMC00480 bm.00167 4.40 2.76E-03 mmc1 #N/A
  13673.m00036 BMX1683 3.03 1.05E-03 Mucin Bm1_11110
Down-regulated
Reproduction, development & transport
  BMC00903 bm.00277 0.47 2.78E-03 Embryonic fatty acid-binding protein
Bm-FAB-1
Bm1_33050
  12495.m00012 BMX108 0.26 8.99E-03 Collagen, putative Bm1_00775
  15377.m00007 BMX9051 0.21 1.75E-03 Alpha-1 collagen type IX, putative Bm1_56350
  AA109462 BMX9336 0.40 5.12E-03 Peptidyl-prolyl cis-trans isomerase Bm1_56870
  BMC03244 bm.00803 0.45 4.98E-03 Prolyl 4-hydroxylase Bm1_45455
  BMC02383 bm.00595 0.44 6.93E-04 Caveolin-1 Bm1_36280
  14700.m00144 BMX3736 0.42 4.38E-03 Cadherin Bm1_24010
Electron transfer
  BMC02188 bm.00554 0.30 2.20E-03 NADH dehydrogenase subunit 5 Bm1_56750