Figure 1
From: Cardiac and vascular phenotypes in the apolipoprotein E-deficient mouse
A hypothetical scheme illustrating the role of ROS and decreased NO bioavailability in vascular dysfunction in conditions of hypercholesterolemia and atherosclerosis in the apoE-/- mouse. Abbreviations: ADMA, asymmetric dimethyl-L-arginine; BH4, tetrahydrobiopterin; eNOS, endothelial nitric oxide synthase; NADPH, nicotinamide adenine dinucleotide phosphate; NO, nitric oxide; •O2-, superoxide anion; •ONOO-, peroxynitrite; PARP, poly-ADP-ribose polymerase; PGI2, prostacyclin; ROS, reactive oxygen species.