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Table 2 Scatchard analysis of [3H]bicuculline binding against bicuculline in the cerebral cortex of control and experimental rats

From: Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

Group Bmax (fmoles/mg ptn) Kd (nM)
C 85.4 ± 4.5 1.7 ± 0.3
E 37.9 ± 3.9*** 0.9 ± 0.1**
E+B 75.0 ± 5.3@@@ 1.2 ± 0.3
E+D 80.1 ± 6.1@@@ 1.39 ± 0.1
E+C 76.5 ± 4.7@@@ 1.38 ± 0.2
  1. Values are mean ± SEM of 4-6 separate experiments. Each group consist of 6-8 rats ** p < 0.01, *** p < 0.001 when compared to control, @@ < 0.01, @@@ < 0.001 when compared to epileptic group. C- Control, E- Epileptic, E+B- Epileptic rats treated with Bacopa monnieri, E+D- Epileptic rats treated with Bacoside A and E+C- Epileptic rats treated with Carbamazepine.