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Table 3 Scatchard analysis of [3H]baclofen binding against Baclofen in the cerebral cortex of control and experimental rats

From: Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

Group Bmax (fmoles/mg ptn) Kd (nM)
C 124.3 ± 8.5 1.8 ± 0.2
E 91.9 ± 6.9*** 1.2 ± 0.1**
E+B 115.2 ± 7.3@@@ 1.6 ± 0.3
E+D 111.7 ± 5.1@@@ 1.3 ± 0.1
E+C 107.1 ± 7.7@@@ 1.4 ± 0.2
  1. Values are mean ± SEM of 4-6 separate experiments. Each group consist of 6-8 rats ** p < 0.01, *** p < 0.001 when compared to control, @@ < 0.01, @@@ < 0.001 when compared to epileptic group. C- Control, E- Epileptic, E+B- Epileptic rats treated with Bacopa monnieri, E+D- Epileptic rats treated with Bacoside A and E+C- Epileptic rats treated with Carbamazepine.