| Control | NASH | MCD+EUK-8 | MCD+EUK-134 | MCD+Vit. C |
---|---|---|---|---|---|
Body Weight (g) | Â | Â | Â | Â | Â |
   Initial | 265 ± 25 | 241 ± 20 | 251 ± 25 | 259 ± 21 | 242 ± 31 |
   Final | 310 ± 28 | 212 ± 21 * | 276 ± 19 †| 298 ± 25 †| 261 ± 23 †|
Liver index (%) | 3.01 ± 0.07 | 3.52 ± 0.09 * | 3.09 ± 0.06 †| 3.11 ± 0.08 †| 3.27 ± 0.21 †|
Serum | Â | Â | Â | Â | Â |
   Albumin (g/dL) | 3.27 ± 0.22 | 3.33 ± 0.16 | 3.17 ± 0.21 | 3.01 ± 0.11 | 3.41 ± 0.25 |
   FBG (mM) | 6.11 ± 0.18 | 11.91 ± 0.28 * | 8.55 ± 0.18 †| 8.85 ± 0.21 †| 9.77 ± 0.23 †|
   Total Cholesterol (mmol/L) | 3.41 ± 0.19 | 5.55 ± 0.32 * | 3.81 ± 0.14 †| 3.68 ± 0.18 †| 4.29 ± 0.24 †|
   HDL-C (mmol/L) | 2.21 ± 0.05 | 1.67 ± 0.06 * | 2.81 ± 0.11 †| 3.04 ± 0.14 †| 2.36 ± 0.09 †|
   LDL-C (mmol/L) | 0.91 ± 0.06 | 1.49 ± 0.18 * | 1.11 ± 0.08 †| 0.94 ± 0.06 †| 1.16 ± 0.07 †|
   AST (U/L) | 110.33 ± 5.23 | 177.12 ± 11.23 * | 145.22 ± 8.33 †| 139.72 ± 12.98 †| 127.61 ± 14.53 †|
   ALT (U/L) | 67.32 ± 4.34 | 100.98 ± 9.22 * | 86.17 ± 6.31 †| 80.11 ± 8.59 †| 76.07 ± 6.21 †|
   ALP (U/L) | 872.42 ± 71.25 | 1849.53 ± 89.21 * | 1221.38 ± 65.29 †| 1134.15 ± 53.91 †| 1378.42 ± 72.78 †|
   GGT (U/L) | 9.61 ± 1.31 | 13.55 ± 1.18 * | 10.85 ± 1.68 †| 10.09 ± 1.11 †| 10.37 ± 1.98 †|
Liver | Â | Â | Â | Â | Â |
   CAT (U) | 2.65 ± 0.07 | 2.25 ± 0.09 * | 2.78 ± 0.11 †| 3.23 ± 0.14 †| 2.91 ± 0.12 †|
   SOD (U) | 4.45 ± 0.16 | 3.38 ± 0.18 * | 4.62 ± 0.21 †| 4.27 ± 0.16 †| 4.09 ± 0.21 †|
   TBARS (nmol/mg liver protein) | 0.34 ± 0.04 | 0.72 ± 0.05 * | 0.52 ± 0.03 †| 0.48 ± 0.06 †| 0.45 ± 0.07 †|
   PCO (nmol/mg liver protein) | 1.41 ± 0.09 | 2.39 ± 0.11 * | 1.94 ± 0.13 †| 2.07 ± 0.09 †| 1.81 ± 0.05 †|