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Table 1 Phenotypic and biochemical parameters.

From: Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress

 

Control

NASH

MCD+EUK-8

MCD+EUK-134

MCD+Vit. C

Body Weight (g)

     

   Initial

265 ± 25

241 ± 20

251 ± 25

259 ± 21

242 ± 31

   Final

310 ± 28

212 ± 21 *

276 ± 19 †

298 ± 25 †

261 ± 23 †

Liver index (%)

3.01 ± 0.07

3.52 ± 0.09 *

3.09 ± 0.06 †

3.11 ± 0.08 †

3.27 ± 0.21 †

Serum

     

   Albumin (g/dL)

3.27 ± 0.22

3.33 ± 0.16

3.17 ± 0.21

3.01 ± 0.11

3.41 ± 0.25

   FBG (mM)

6.11 ± 0.18

11.91 ± 0.28 *

8.55 ± 0.18 †

8.85 ± 0.21 †

9.77 ± 0.23 †

   Total Cholesterol (mmol/L)

3.41 ± 0.19

5.55 ± 0.32 *

3.81 ± 0.14 †

3.68 ± 0.18 †

4.29 ± 0.24 †

   HDL-C (mmol/L)

2.21 ± 0.05

1.67 ± 0.06 *

2.81 ± 0.11 †

3.04 ± 0.14 †

2.36 ± 0.09 †

   LDL-C (mmol/L)

0.91 ± 0.06

1.49 ± 0.18 *

1.11 ± 0.08 †

0.94 ± 0.06 †

1.16 ± 0.07 †

   AST (U/L)

110.33 ± 5.23

177.12 ± 11.23 *

145.22 ± 8.33 †

139.72 ± 12.98 †

127.61 ± 14.53 †

   ALT (U/L)

67.32 ± 4.34

100.98 ± 9.22 *

86.17 ± 6.31 †

80.11 ± 8.59 †

76.07 ± 6.21 †

   ALP (U/L)

872.42 ± 71.25

1849.53 ± 89.21 *

1221.38 ± 65.29 †

1134.15 ± 53.91 †

1378.42 ± 72.78 †

   GGT (U/L)

9.61 ± 1.31

13.55 ± 1.18 *

10.85 ± 1.68 †

10.09 ± 1.11 †

10.37 ± 1.98 †

Liver

     

   CAT (U)

2.65 ± 0.07

2.25 ± 0.09 *

2.78 ± 0.11 †

3.23 ± 0.14 †

2.91 ± 0.12 †

   SOD (U)

4.45 ± 0.16

3.38 ± 0.18 *

4.62 ± 0.21 †

4.27 ± 0.16 †

4.09 ± 0.21 †

   TBARS (nmol/mg liver protein)

0.34 ± 0.04

0.72 ± 0.05 *

0.52 ± 0.03 †

0.48 ± 0.06 †

0.45 ± 0.07 †

   PCO (nmol/mg liver protein)

1.41 ± 0.09

2.39 ± 0.11 *

1.94 ± 0.13 †

2.07 ± 0.09 †

1.81 ± 0.05 †

  1. Data are presented as means ± SD (n = 6) of triplicate measurements of each sample. * P < .05 compared to control. † P < .05 compared to NASH group.