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Table 3 Correlation of the expression of the pro-inflammatory cytokines and osteoclasts' specific genes and RANK/RANKL/OPG genes

From: The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues

Gene mRNA

OSCAR

β3 integrin

Cathepsin K

TRAP

Calcitonin receptor

RANK

RANKL

OPG

Ligand/Receptor mRNA ratio

OP

OA

OP

OA

OP

OA

OP

OA

OP

OA

OP

OA

OP

OA

OP

OA

IL6/IL6R

-0.282

-0.215

0.587*

-0.363*

-0.451*

0.519**

-0.329

0.319

-0.431*

0.656**

-0.421

0.658**

0.083

0.619**

-0.147

0.529**

IL1A/IL1R1

-0.181

-0.156

0.239

0.137

-0.508*

-0.166

-0.350

0.021

-0.494*

-0.434*

-0.311

-0.301

-0.259

-0.258

-0.484*

-0.296

IL1A/IL1R2

-0.021

-0.380*

0.100

-0.005

-0.103

0.325

0.015

0.348

-0.084

0.207

0.027

0.305

-0.066

0.337

-0.491*

0.271

TGFB1/TGFBR1

0.054

-0.198

0.112

0.256

0.473*

-0.075

0.486*

0.048

0.302

-0.201

0.531*

-0.051

0.263

-0.208

0.027

-0.033

IL17A/IL17RA

0.007

0.030

-0.116

0.167

-0.491*

-0.081

-0.263

-0.084

-0.600**

0.087

-0.605**

0.002

-0.293

-0.009

0.068

0.021

IL17A/IL17RC

-0.140

0.010

-0.358

-0.070

-0.390

-0.154

0.213

-0.004

-0.600*

-0.095

-0.537*

-0.096

-0.005

-0.027

0.213

-0.004

IFNG/IFNGR1

0.198

-0.181

-0.601**

-0.062

0.119

0.205

-0.018

0.097

0.191

0.120

-0.070

0.207

-0.197

0.296

0.337

0.167

IFNB1/IFNAR1

0.224

0.006

0.095

0.188

-0.553**

-0.283

-0.453*

-0.290

-0.527**

-0.038

-0.580**

-0.202

-0.447*

-0.186

0.002

-0.070

IFNB1/IFNAR2

0.313

-0.049

0.013

0.107

-0.510*

-0.137

-0.430*

-0.152

-0.463*

0.064

-0.517*

-0.052

-0.456*

-0.035

0.043

0.063

TNF/TNFRSF1A

0.329

0.292

-0.038

0.018

-0.428*

-0.632**

-0.429*

-0.598**

-0.414*

-0.613**

-0.362

-0.631**

-0.356

-0.541**

0.192

-0.534**

  1. OSCAR osteoclast associated immunoglobulin-like receptor. TRAP tartrate resistant acid phosphatase. RANK receptor activator of nuclear factor κB. RANKL RANK ligand. OPG osteoprotegerin.
  2. The numbers are Spearman's rho coefficients for osteoporotic (OP) and osteoarthritic (OA) tissue. p values were obtained using nonparametric bivariate correlation analysis, *p < 0.05, **p < 0.01. Significant positive correlations are underlined with bold line.