Figure 5

Possible molecular mechanism for IH-induced cell death in rat cerebellar granule cells. IH causes elevated oxidative stress and induces cell apoptosis and necrosis. Overactivation of PARP causes ATP depletion, leading to cell necrosis. PARP activation also generates PAR polymers, activates mitochondrial calpain, which induce AIF translocation to the nucleus and lead to cell apoptosis.