Skip to main content
Figure 1 | Journal of Biomedical Science

Figure 1

From: In Silico profiling of deleterious amino acid substitutions of potential pathological importance in haemophlia A and haemophlia B

Figure 1

Structural representation of FVIII (2R7E) native and mutant proteins. a. Structure of FVIII native type protein (2R7E) in grey displaying the position of W274, W412, W2065 and W2232 in sphere shape (green color). b. Superimposed structure of native amino acid tryptophan in sphere shape (green color) with mutant amino acid cysteine (red color) at position 274 in ‘A’ chain of 2R7E. c. Superimposed structure of native amino acid tryptophan in sphere shape (green color) with mutant amino acid arginine (red color) at position 412 in ‘A’ chain of 2R7E. d. Superimposed structure of native amino acid tryptophan in sphere shape (green color) with mutant amino acid arginine (red color) at position 2065 in ‘B’ chain of 2R7E. e. Superimposed structure of native amino acid tryptophan in sphere shape (green color) with mutant amino acid arginine (red color) at position 22232 in ‘B’ chain of 2R7E.

Back to article page