Table 1 Concordance analysis between SIFT and PolyPhen in the prediction of functional variants in F8 and F9
SIFT | No of Variants | PolyPhen | No of Variants | ||||
|---|---|---|---|---|---|---|---|
Scores | Prediction | F8 | F9 | Scores | Prediction | F8 | F9 |
0.00-0.05 | Intolerant | 378 | 129 | ≥ 2.000 | Probably damaging | 183 | 105 |
0.051-0.10 | Potentially intolerant | 45 | 7 | 1.500-1.999 | Possibly damaging | 188 | 26 |
0.101-0.20 | Borderline | 43 | 8 | 1.25-1.49 | Potentially damaging | 70 | 8 |
0.201-1.00 | Tolerant | 44 | 21 | 1.00-1.24 | Borderline | 49 | 3 |
| Â | Â | Â | Â | 0.000-0.999 | Benign | 20 | 23 |
Total | 510 | 165 | Total | 510 | 165 | ||