Skip to main content

Table 1 Concordance analysis between SIFT and PolyPhen in the prediction of functional variants in F8 and F9

From: In Silico profiling of deleterious amino acid substitutions of potential pathological importance in haemophlia A and haemophlia B

SIFT No of Variants PolyPhen No of Variants
Scores Prediction F8 F9 Scores Prediction F8 F9
0.00-0.05 Intolerant 378 129 ≥ 2.000 Probably damaging 183 105
0.051-0.10 Potentially intolerant 45 7 1.500-1.999 Possibly damaging 188 26
0.101-0.20 Borderline 43 8 1.25-1.49 Potentially damaging 70 8
0.201-1.00 Tolerant 44 21 1.00-1.24 Borderline 49 3
     0.000-0.999 Benign 20 23
Total 510 165 Total 510 165