Figure 2
From: The role of thrombomodulin lectin-like domain in inflammation
TM suppresses HMGB1-mediated inflammation. HMGB1 mediated-pro-inflammatory pathways are inhibited by TM through two mechanisms. First, Soluble TMD1 sequesters HMGB1, and results in decreasing its binding to RAGE, thereby suppressing the inflammatory response. Second, thrombin-TM complex cleaves HMGB1, resulting in generation of inactive HMGB1 fragment. HMGB1, high mobility group B1; RAGE, receptor for advanced glycation end products; TMD1, TM domain 1.