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Figure 1 | Journal of Biomedical Science

Figure 1

From: STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death

Figure 1

Distinct effects of STI571 on TRAIL-induced cytotoxicity in cancer cells. K562 cells (A), colon cancer HCT116 cells (B), and SW480 cells (C) were pretreated with STI571 for 30 min, followed by TRAIL for 24 h, and then the cell viability was assessed by an MTT assay. Cell viability was determined in some cases of K562 (A, right panel) and HCT116 cells (B, right panel) after drug treatment for different periods. In (D), various cancer cells were treated with STI571 (1 μM) and TRAIL (50 ng/ml) for 24 h, and then the cell viability was determined. * p < 0.05, indicating significant attenuation of TRAIL-induced cytotoxicity by STI571

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