Skip to main content
Figure 6 | Journal of Biomedical Science

Figure 6

From: STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death

Figure 6

STI571-induced cell resistance to TRAIL is dependent on p73. (A) HCT116 cells were transfected with p73 siRNA, and were treated with TRAIL (50 ng/ml) and/or STI571 (0.3 μM) as indicated. Cell viability at 24 h and protein expression of p73 were determined. * p < 0.05, indicating a significant reduction of TRAIL-induced apoptosis by STI571. # p < 0.05, indicating a significant difference of TRAIL-elicited cell death between p73 siRNA and scrambled control cells. In some experiments, caspase 3 (B), JNK and p38 activations (C) were measured by assessing their cleavage form and phosphorylation state. Data of immunoblotting were representative of three separate experiments with similar results.

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127