Table 1 Immunostaining expression of PKCζ in normal parenchymal and RCC tissues
From: Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications
Patients | PKCζ protein expression (mean score ± SE) | |||
|---|---|---|---|---|
Characteristic | No. (%) | Normal renal tubular cells | RCC | P value* |
Total | 144 (100) | 161.1 ± 4.5 | 103.6 ± 4.5 | < 0.0001 |
Sex | ||||
Male | 98 (68) | 158.5 ± 5.4 | 103.3 ± 5.5 | < 0.0001 |
Female | 46 (32) | 166.5 ± 8.0 | 104.3 ± 7.9 | < 0.0001 |
P value† | 0.41 | 0.91 | ||
Grade | ||||
I | 19 (13) | 166.8 ± 13.1 | 79.5 ± 10.6 | < 0.0001 |
II | 64 (45) | 160.8 ± 6.7 | 101.7 ± 6.8 | < 0.0001 |
III | 32 (22) | 168.1 ± 8.9 | 113.8 ± 9.1 | < 0.0001 |
IV | 15 (10.3) | 166 ± 10.9 | 111.3 ± 15.1 | 0.009 |
ND | 14 (9.7) | 132.9 ± 18.1 | 109.3 ± 17.2 | 0.3 |
P for ANOVA‡ | 0.91 | 0.14 | ||
P for trend¶ | 0.79 | 0.04 | ||
Stage | ||||
Organ-confined (T1-2N0 M0) | 95 (66) | 159.1 ± 5.8 | 102.1 ± 5.6 | < 0.0001 |
Locally advanced (T3-4 N0 M0) | 31 (22) | 160 ± 10.2 | 103.9 ± 8.5 | < 0.0001 |
Metastatic (N1-2 or M1) | 17 (11.3) | 162.4 ± 11.3 | 115.3 ± 15.7 | 0.032 |
ND | 1 (0.7) | 200 | 50 | |
P for ANOVA‡ | 0.97 | 0.67 | ||
P for trend¶ | 0.41 | 0.13 | ||
Histological type | ||||
Conventional | 108 (75) | 163.1 ± 4.9 | 98.1 ± 4.7 | < 0.0001 |
Non-conventional | 36 (25) | 152.2 ± 11.2 | 115.6 ± 11.5 | 0.0082 |
P value† | 0.31 | 0.098 | ||