StAR and 3-beta-HSD expression. Downregulation of mRNA or protein expression of StAR and 3-beta-HSD was significant in rat testis suffering from hypoxia exposure for 4 weeks and was relieved by CPU86017-RS and Nif, medicated in the last 2 weeks. A, StAR mRNA; B, StAR protein; C, 3-beta-HSD mRNA; D, 3-beta-HSD protein. Mean ± SD, n = 10. *P < 0.05, **P < 0.01, vs. Normal; #P < 0.05, # #P < 0.01, vs. Hypoxia, $P < 0.05, vs. H+RSL (RS low dose).