Figure 3

Chromosome 7 polysomy and membrane EGFR protein expression determined as percentage of EGFR immunohistochemicaly positive cells per tumor (%), EGFR total H-score (tH-score) and EGFR continuous H-score (cH-score) in clear cell renal cell carcinoma (CCRCC). Low and high categories of EGFR immunohistochemical staining are designated according to median cut off value. Student's t-test is showing higher percentage of tumor cells with chromosome 7 polysomy to be significantly associated with high expression of all EGFR immunohistochemical staining categories: (a) EGFR % (p = 0.001); (b) EGFR tH-score (p < 0.001); (c) EGFR cH-score (p < 0.001).