Figure 4

Huntingtin regulates prespore/spore differentiation cell-autonomously. (A) GFP was expressed in htt^- cells and their position in chimeras with unlabelled wild type cells was monitored. GFP:htt^- cells fail to populate the prespore domain. (B) Reverse experiment in which GFP: WT cells in chimeras with unlabelled htt^- cells occupy the prespore domain. The prestalk (pst) and prespore (psp) domains are underlined. Cell types within each region are shown and slugs are arranged with the front facing towards the right. Permission: Myre M.A. et al. (2009). Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum. PLoS Genetics, 7(4), pp. e1002052.