Induction of mRANTES expression by test phytochemicals in mouse skin tissues. Mouse skin was either untreated, or treated with vehicle control solvent, gallic acid (GA), ferulic acid (FA), curcumin (CM), caffeic acid (CA), epigallocatechin gallate (EGCG) or shikonin (SK), each at 0.7 mmole/site/mouse. TPA and hydrocortisone (H) were used as a positive and negative control, respectively. Skin samples were collected at 24 h post treatment and mRANTES expression was determined by ELISA analysis. *, P < 0.05; ***, P < 0.001, versus solvent treatment. Error bars indicate SD.