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Figure 9 | Journal of Biomedical Science

Figure 9

From: The treatment of glioblastoma multiforme through activation of microglia and TRAIL induced by rAAV2-mediated IL-12 in a syngeneic rat model

Figure 9

Tumor growth and survival rate of rAAV2/IL12-treated and PBS-treated rats. Tumor growth was evaluated with brain slices harvested on the last day of week-1 (n = 3 each group), week-2 (n = 3 each group), and week-3 (n = 3 each group) post tumor implantation. The black arrows indicate the brain sections composed of maximal tumor mass, for delineation and estimation of tumor volume. The scale bar indicates 2 mm. A-C. rAAV2/IL12-treated tumors grew for 2 weeks. D-F. PBS-treated tumors grew for 2 weeks. G-I. rAAV/IL12-treated tumors grew for 3 weeks. J-L. PBS-treated tumors grew for 3 weeks. M. Mean tumor volume was estimated with Axiovision Rel. 4.7, Carl Zeiss Microimaging, Stuttgart, Germany. N. The survival rate of rats was analyzed with Kaplan Meier method. The black line represents the survival curve of rAAV/IL12-treated rats and the dot black line represents the survival curve of PBS-treated rats.

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