Figure 10
De-ubiqutination is crucially involved in maintaining survival during experimental brain death. Survival rate of rats that received pretreatment by microinjection bilaterally into RVLM of ubiquitin aldehyde (UbAD; upper diagram), UCH-L1 inhibitor (UCH-L1i; lower diagram) or their solvents (Vehicle), followed by intravenous administration (at arrows) of LPS (15 mg kg-1) or saline. Values are mean ± SEM, n = 7–8 animals at the beginning of the experiment. Significant difference versus Vehicle + LPS group in the Fisher exact test.