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Table 1 Sequence alignment of two representatives of each subfamily of the metzincins

From: A smallest 6 kda metalloprotease, mini-matrilysin, in living world: a revolutionary conserved zinc-dependent proteolytic domain- helix-loop-helix catalytic zinc binding domain (ZBD)

  Zinc-binding Signature Met-turn
ADAM TAAHQLGHVFNMLHDNSK PLSTSRHVMAPVMAHVD
Astacin TIIHELMHAIGFYHEHT EDYQYYSIMHYGKYSFS
Adamalysin II TMAHELGHNLGMEHDGK LRGASLCIMRPGLTPGR
Matrilysin AATHELGHSLGMGHSSD HSSDPNAVMYPTYGNGD
  1. Only the sections containing the zinc-binding histidine residues and the Met-loop areshown. The histidine zinc-ligands, the catalytically active glutamic acid residue, the residue directly following the third His ligand, the conserved Met residue, and the two positions after the Met are in.
  2. a Pseudomonas aeruginosa alkaline proteinase.
  3. b 3.4.24.11 protease.
  4. PDB code: (ADAM: 2RJP[20], Astacin: 1QJI[21], Adamlysin II: 2AIG[22], HumanMMP-7: 1MMR[3], P. aeruginosa alkaline protease: 1AKL[23], 3.4.24.11 protease: 1THL[10].)