Figure 5
From: Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis
Fos and CGRP immunoreactivity in the spinal cord in affected and unaffected mice. (A) No Fos expression was found in the spinal cord in unaffected mice. (B) Fos immunoreactivity was detected in the dorsal horn in autoinflammation mice. (C) A positive control used formalin injection into the paws of unaffected mice. Fos expression was enhanced in the dorsal horn of the spinal cord. (D) The densest part of CGRP labeling was in the laminar II layer of the dorsal horn of the spinal cord. CGRP immunostaining revealed no detectable fibers in laminae III-V in the spinal cord in unaffected mice. (E) CGRP-immunoreactive fibers in laminae III-V of the spinal cord were enhanced in autoinflammation mice.