Pharmacologic inhibition of phosphoinositide-3-kinase (PI3K) isoform γ decreases Ca2+, [Ca2+]
, in HL-1 cell mouse cardiomyocytes. A. Effect of AS-252424 (100 nM) on [Ca2+]i oscillations in five representative HL-1 cells. Time base applies to all traces. B. Effect of AS-252424 (100 nM) on average [Ca2+]i in cells displaying oscillating and non-oscillating [Ca2+]i (mean ± SEM; n = 5, each an average of 25 to 40 cells as shown in A.