Figure 4

Pharmacologic inhibition of phosphoinositide-3-kinase (PI3K) isoform γ decreases Ca²⁺, [Ca²⁺] _i , in HL-1 cell mouse cardiomyocytes. A. Effect of AS-252424 (100 nM) on [Ca²⁺]_i oscillations in five representative HL-1 cells. Time base applies to all traces. B. Effect of AS-252424 (100 nM) on average [Ca²⁺]_i in cells displaying oscillating and non-oscillating [Ca²⁺]_i (mean ± SEM; n = 5, each an average of 25 to 40 cells as shown in A.