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Table 1 Effect of phosphoinositide-3-kinase inhibitor LY 294002 on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent

(Concentration)

Target

Control

[Ca2+]i, (nM)

Inhibitor (15 min)

[Ca2+]i, (nM)

P value for difference

LY 294002

(1 μM)

PI3K

141.6 ± 10.1

124.9 ± 6.9

<0.03

LY 294002

(10 μM)

PI3K

160.6 ± 24.4

134.8 ± 12.0

=0.29

LY 294002

(20 μM)

PI3K

132.6 ± 5.2

117.1 ± 6.1

<0.003

  1. Mean ± SEM (n = 3 or 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).
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Journal of Biomedical Science

ISSN: 1423-0127