Skip to main content

Table 1 Effect of phosphoinositide-3-kinase inhibitor LY 294002 on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent
(Concentration)
Target
Control
[Ca2+]i, (nM)
Inhibitor (15 min)
[Ca2+]i, (nM)
P value for difference
LY 294002
(1 μM)
PI3K
141.6 ± 10.1 124.9 ± 6.9 <0.03
LY 294002
(10 μM)
PI3K
160.6 ± 24.4 134.8 ± 12.0 =0.29
LY 294002
(20 μM)
PI3K
132.6 ± 5.2 117.1 ± 6.1 <0.003
  1. Mean ± SEM (n = 3 or 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).