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Table 2 Effect of phosphoinositide-3-kinase α inhibitor on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent
(Concentration) Target
Control
[Ca2+]i, (nM)
Inhibitor (15 min)
[Ca2+]i, (nM)
P value for difference
PI3K α inhibitor 2
(2 nM)
α
136.4 ± 8.6 118.3 ± 5.9 <0.02
PI3K α inhibitor 2
(4 nM)
α
114.9 ± 4.3 102.1 ± 2.5 <0.01
PI3K α inhibitor 2
(8 nM)
α
131.7 ± 9.0 110.5 ± 4.7 =0.06
  1. Mean ± SEM (n = 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).