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Table 2 Effect of phosphoinositide-3-kinase α inhibitor on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent

(Concentration) Target

Control

[Ca2+]i, (nM)

Inhibitor (15 min)

[Ca2+]i, (nM)

P value for difference

PI3K α inhibitor 2

(2 nM)

α

136.4 ± 8.6

118.3 ± 5.9

<0.02

PI3K α inhibitor 2

(4 nM)

α

114.9 ± 4.3

102.1 ± 2.5

<0.01

PI3K α inhibitor 2

(8 nM)

α

131.7 ± 9.0

110.5 ± 4.7

=0.06

  1. Mean ± SEM (n = 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).