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Table 3 Effect of phosphoinositide-3-kinases β and γ inhibitors on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent
(Concentration) Target
Control
[Ca2+]i, (nM)
Inhibitor (15 min)
[Ca2+]i, (nM)
P value for difference
TGX-221
(100 nM)
β
105.5 ± 5.0 96.6 ± 4.8 <0.03
AS-252424
(100 nM)
γ
121.8 ± 4.3 111.9 ± 6.0 <0.03
  1. Mean ± SEM (n = 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).