Skip to main content

Table 4 Effect of Akt-PKB inhibitor on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent
(Concentration) Target
Control
[Ca2+]i, (nM)
Inhibitor (15 min)
[Ca2+]i, (nM)
P value for difference
Triciribine
(1 μM)
Akt-PKB
177.4 ± 5.2 157.7 ± 1.9 <0.05
Triciribine
(10 μM)
Akt-PKB
125.7 ± 4.4 104.6 ± 4.8 <0.03
Triciribine
(20 μM)
Akt-PKB
216.8 ± 4.1 203.9 ± 1.4 =0.13
  1. Mean ± SEM (n = 3 or 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).