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Table 4 Effect of Akt-PKB inhibitor on intracellular Ca 2+ concentration recorded 15 minutes after addition of respective inhibitors

From: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes

Agent

(Concentration) Target

Control

[Ca2+]i, (nM)

Inhibitor (15 min)

[Ca2+]i, (nM)

P value for difference

Triciribine

(1 μM)

Akt-PKB

177.4 ± 5.2

157.7 ± 1.9

<0.05

Triciribine

(10 μM)

Akt-PKB

125.7 ± 4.4

104.6 ± 4.8

<0.03

Triciribine

(20 μM)

Akt-PKB

216.8 ± 4.1

203.9 ± 1.4

=0.13

  1. Mean ± SEM (n = 3 or 5 experiments each, with each experiment comprising the average [Ca2+] of 25 to 40 cells).
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Journal of Biomedical Science

ISSN: 1423-0127