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Figure 7 | Journal of Biomedical Science

Figure 7

From: Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats

Figure 7

Survival of rabies virus-infected rats treated with passive immunotherapy alone or in combination with BBBO. (A) Diagram of treatment schedule: on day 7 and 9 p.i., group 1 animals received mAb 8-10E alone (n = 7) and group 2 animals received mAb 8-10E + BBBO (n = 8), (B) Survival of rats following infection with four different treatment: (1) 8-10E alone on day 7 p.i., (2) 8-10E + BBBO on day 7 p.i., (3) 8-10E alone on day 9 p.i., and (4) 8-10E + BBBO on day 9 p.i.. Rats were monitored for morbidity and mortality for 40 days. 8-10E: indicated that rats was injected with virus-neutralizing mAb 8-10E. BBBO: indicated that the BBB permeability was enhanced with hypertonic arabinose infusion. Statistical significance of differences in survival rats was denoted by the symbol *p<0.05. (C) Detection of viral RNA in the brain tissues infected with rabies virus. Viral nucleoprotein mRNA expression was detected in the cerebrum, cerebellum and spinal cord of rats died of BBBO and mAb 8-10E + BBBO treatment on day 14 p.i. (numbered 1, 2, 3, 4). The size of the amplified fragment was estimated to be 777 bp. No viral genome was detected in the brain tissues and spinal cord of rats survived for 40 day p.i. (numbered 5, 6, 7, 8). The lane marked “P” is the positive control taken from a cultured virus suspension.

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