Figure 9

The effect of the RRM-designed peptides on human erythrocytes. Washed human erythrocytes in PBS were incubated for 18 h with the following concentrations of RRM-MVor RRM-C: 50 ng/mL; 100 ng/mL; 200 ng/mL; 400 ng/mL; 600 ng/mL; 800 ng/mL; 100 ng/mL; 1200 ng/mL; 1400 ng/mL; and1600 ng/mL. Human red blood cells were relatively resistant to RRM-MV and RRM-C treatment when incubated for up to 18 h, as cytolytic/hemolytic effects were not detected after treatment with both peptides. Data values are the average of three independent experiments in triplicates.