Figure 2

Possible mechanisms of EPI. Effect of pretreatment of animals with naloxone (2 mg/kg s.c Figure 2A), glibenclamide (2 mg/kg s.c Figure 2B), yoimbine (0,15 mg/kg s.c Figure 2C), pindolol (1 mg/kg s.c Figure 2D) e atropine (0,2 mg/kg s.c Figure 2E) on the antinociceptive profiles of the (−) epicatequin (EPI) administered orally against glutamate-induced nociception in mice. Each column represents the mean ± S.E.M. of 6 animals. Control value (C) indicates the animals treated with vehicle and the asterisks denote the significance levels, when compared with control groups (one-way ANOVA followed by Bonferroni test) (*P < 0,005; **p < 0,01 e ***p < 0,001).