Figure 1
From: Characterization of Mg2+-regulated TRPM7-like current in human atrial myocytes
Presence of TRPM7-like current in human atrial myocytes of patients with normal SR. Original traces of endogenous currents without (A) and with already up- regulated TRPM7-like current (B, notice outward rectification) obtained using voltage ramps (see insert) at cell membrane rupture are plotted against voltage. The arrow indicates current peak value (at +80 mV and - 120 mV) at rupture. Summary values (± S.E.M., and n-cells/patients) of endogenous (white) and already up-regulated (grey) currents: at rupture (~1 min; plane), after 30 min of dialysis with EGTA (striped), and EDTA (crossed) as indicated at +80 (C) and - 120 mV (D). Dot line indicates endogenous current density at rupture. Differences between endogenous and already up-regulated currents at rupture as well as steady state values of TRPM7-like current were significant (*P <0.001) when paired t test and ANOVA were used.