Figure 5

TRPM7-like current regulation by extracellular divalent cations. Unmasked current in extracellular DVF medium during dialysis with ~5 mM free-Mg_i²⁺ (A) or 5 mM MgATP (B): at +80 (○) and −120 mV (). The DVF extracellular solution contained 100 μM of nifedipine, and Mg²⁺ (7.2 mM), Ca²⁺ (1.8 mM), SpM⁴⁺ (100 μM), or carvacrol (100 μM) added on top. In inserts – I/V relations: Cs⁺-Tyrode (), DVF (ο), Mg²⁺ (▴), Ca²⁺ (■), SpM⁴⁺ (□), or carvacrol (Δ). Permeability to divalent cations at +80 (C) and -120 mV (D), and mean data in inserts, respectively.