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Figure 1 | Journal of Biomedical Science

Figure 1

From: Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

Figure 1

Cardiovascular effects following microinjection bilaterally into the RVLM of E2β, ERα or ERβ agonist. Time-course of the changes in mean systemic arterial pressure (MSAP), heart rate (HR) and total power density of vasomotor components (0–0.8 Hz) of systemic arterial pressure (SAP) spectrum in anaesthetized rats that received microinjection bilaterally into the rostral ventrolateral medulla (RVLM, at time 0) of artificial cerebrospinal fluid (aCSF), 17β-estradiol (E2β, 1 pmol), diarylpropionitrile (DPN, 1, 2 or 5 pmol) or 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1 H-pyrazole (PPT, 5 pmol). Values are presented as the mean ± SEM; n = 6-8 animals per experimental group. *P < 0.05 versus aCSF group in the post hoc Scheffé multiple-range test.

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Journal of Biomedical Science

ISSN: 1423-0127