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Figure 2 | Journal of Biomedical Science

Figure 2

From: Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

Figure 2

Effects of ER antagonist on the E2β agonist-induced vasodepressive responses. Time-course of the changes in MSAP and total power density of vasomotor components (0–0.8 Hz) of SAP spectrum in anaesthetized rats that received microinjection bilaterally into the RVLM (at time 0) of aCSF, or DPN (2 pmol) given together with ICI 182780 (ICI, 0.25 or 0.5 pmol), R,R-THC (50 pmol), MPP (1 nmol) or 5 % DMSO. Values are presented as the mean ± SEM; n = 6-8 animals per experimental group. *P < 0.05 versus aCSF group and #P < 0.05 versus DPN + DMSO group in the post hoc Scheffé multiple-range test.

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