Figure 3

Effects of ERα or ERβ ASON on the ERβ agonist-induced vasodepressive responses. Time-course of the changes in MSAP and total power density of vasomotor components (0–0.8 Hz) of SAP spectrum in anaesthetized rats that received microinjection bilaterally into the RVLM (at time 0) of aCSF, or to rats pretreated with ERα ASON (250 pmol), ERα SCR (250 pmol), ERβ ASON (250 pmol), ERβ SCR (250 pmol) or aCSF, administered into the bilateral RVLM 24 hours before DPN (2 pmol) microinjection. Values are presented as the mean ± SEM; n = 6-7 animals per experimental group. ^*P < 0.05 versus aCSF group and ^#P < 0.05 versus aCSF + DPN group in the post hoc Scheffé multiple-range test.