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Figure 4 | Journal of Biomedical Science

Figure 4

From: Nontranscriptional activation of PI3K/Akt signaling mediates hypotensive effect following activation of estrogen receptor β in the rostral ventrolateral medulla of rats

Figure 4

Effects of RNA synthesis inhibitor on the ERβ agonist-induced vasodepressive responses. Time-course of the changes in MSAP and total power density of vasomotor components (0–0.8 Hz) of SAP spectrum in anaesthetized rats that received microinjection bilaterally into the RVLM (at time 0) of aCSF, or to rats pretreated with actinomycin D (AMD, 5 or 10 nmol) or 5 % DMSO, administered into the bilateral RVLM 1 hour before DPN (2 pmol) microinjection. Values are presented as the mean ± SEM; n = 7-8 animals per experimental group. *P < 0.05 versus aCSF group in the post hoc Scheffé multiple-range test.

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