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Figure 3 | Journal of Biomedical Science

Figure 3

From: Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis

Figure 3

Histology of knee joints with Safranin O staining at Day14. Three different magnifications (×1.25, ×10, ×20) were shown in each group. (a-c) Naïve model: Full thickness of cartilage. Rich chondrocytes with proteoglycan (red staining by safranin O) (d-f) OA model: Severe damage of cartilage surface with loss of chondrocytes in superficial and middle layer (#), hypertrophied chondrocytes in deep zone (white arrow) were observed in (f) . Increased thickening of subchondral bone subjacent to the area of severe cartilage lesion was also observed in (d,e). (g-i) APETx2 administration in early phase: Chondrocytes were well observed in superficial and middle layer (black arrow). Although proteoglycan loss, cartilage surface kept smooth and no apparent thinning (*) in (i). (j-l) APETx2 in late phase: same findings as OA. Apparent chondroprotective effect was not seen (#) and hypertrophied chondrocytes in deep zone were also observed (white arrow) in (l). F: femur, M: meniscus, T: tibia, Scale bar: 1 mm, 100 μm, 50 μm.

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