Figure 4
From: Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis
The effect of intra-articular injection of APETx2 on behavior tests. (a)weight distribution, (b) paw withdrawal reflex (same manner as Figure1). Weight distribution was changed significantly at Day3 in early APETx2 administration group. Frequency of paw withdrawal reflex i.e. secondary hyperalgesia reduced with APETx2 injection. The inhibitory effects on secondary hyperalgesia in both early- and late-phase groups were observed at Day14. * p < 0.05 (Early vs OA), # p < 0.05 (Late vs OA).