|
Behavior after 4 AP Injection
|
|---|
|
RAT
|
Minutes
|
|---|
|
15
|
30
|
45
|
60
|
120
|
180
|
|---|
|
1–5 (A)
|
0/1/2/3
|
0/1/2/3
| | | | |
|
6–10 (B)
|
0/1/2
|
0/1/2/3/4
|
0/1/2/3/4
|
0/1/2/3
| | |
|
11–15 (C)
|
0/1/2/3
|
1/2/3/4
|
0/1/2/3/4
|
0/1/2/3/4
|
0/1/2/3
|
0/1/2/3
|
- The values represent seizure behavior according to the modified Racine Scale [23]: 0, behavioral arrest (motionless), piloerection, excitement and rapid breathing; 1, movement of the mouth, lips tongue and vibrissae, salivation; 2, head clonus and eye clonus; 3, forelimb clonus, “wet dog shakes”; 4, clonic rearing; 5, clonic rearing with loss of postural control and uncontrolled jumping.
- The rats were sacrificed 30 (A), 60 (B) or 180 (C) min after 4-AP injection.
