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Figure 2 | Journal of Biomedical Science

Figure 2

From: Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells

Figure 2

Zerumbone evoked caspase-3 activation in GBM cells . (A) GBM8401 cells were pretreated with DMSO or zVAD-fmk (50 or 100 μM) for 30 min before the addition of zerumbone (50 μM) for another 24 h. Cell viability was then determined by the MTT assay. *p < 0.05, compared with the group treated with zerumbone alone. Cells were treated with DMSO or zerumbone (50 μM) for indicated time intervals. Protein levels of procaspase-3 and caspase-3 (B) and PARP (C) were then determined by immunoblotting. Typical traces, representive of data from 3 independent experiments with similar results, are shown.

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